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1

Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J., Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha,

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 914 KB

english, 2010

2

Effect of dl-α-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium

Nigel Yarlett, Cyrus J. Bacchi

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 648 KB

english, 1988

3

Trypanosoma brucei brucei: Regulation of ornithine decarboxylase in procyclic forms and trypomastigotes

Cyrus J. Bacchi, Joanne Garofalo, Angela Santana, Joseph C. Hannan, Alan J. Bitonti, Peter P. McCann

Journal:

Experimental Parasitology

Year:

1989

Language:

english

File:

PDF, 751 KB

english, 1989

4

Synthesis and Anti-Trypanosomal Activity of Various 8-Aza-7-deaza-5‘-noraristeromycin Derivatives

Seley, Katherine L., Schneller, Stewart W., Rattendi, Donna, Lane, Schennella, Bacchi, Cyrus J.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 158 KB

english, 1997

5

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents

Zhili Li, Michael W Fennie, Bruce Ganem, Matthew T Hancock, Muris Kobašlija, Donna Rattendi, Cyrus J Bacchi, Mary C O'Sullivan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 175 KB

english, 2001

6

Trypanocidal Diarylheptanoids from Aframomum letestuianum

Kamnaing, Pierre, Tsopmo, Apollinaire, Tanifum, Eric A., Tchuendem, Marguerite H. K., Tane, Pierre, Ayafor, Johnson F., Sterner, Olov, Rattendi, Donna, Iwu, Maurice M., Schuster, Brian, Bacchi, Cyrus

Journal:

Journal of Natural Products

Year:

2003

Language:

english

File:

PDF, 53 KB

english, 2003

7

Subcellular Localization of the Enzymes of the Arginine Dihydrolase Pathway in Trichomonas vaginalis and Tritrichomonas foetus

NIGEL YARLETT, DONALD G. LINDMARK, BURT GOLDBERG, M. ALI MOHARRAMI, CYRUS J. BACCHI

Journal:

Journal of Eukaryotic Microbiology

Year:

1994

Language:

english

File:

PDF, 695 KB

english, 1994

8

Crithidia fasciculata: Acriflavine-induced changes in soluble enzyme levels

Cyrus J. Bacchi, George C. Hill

Journal:

Experimental Parasitology

Year:

1972

Language:

english

File:

PDF, 762 KB

english, 1972

9

S-Adenosylmethionine synthetase in bloodstream Trypanosoma brucei

Yarlett, Nigel, Garofalo, Joanne, Goldberg, Burt, Ciminelli, Mary Ann, Ruggiero, Vincent, Sufrin, Janice R., Bacchi, Cyrus J.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1993

Language:

english

File:

PDF, 838 KB

english, 1993

10

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela, Büscher, Philippe

Journal:

PLoS Neglected Tropical Diseases

Year:

2011

Language:

english

File:

PDF, 1.39 MB

english, 2011

11

Anti-Trypanosomal Alkaloids from Xymalos Monospora

Ngamga, Dieudonne, Tane, Pierre, Rattendi, Donna, Bacchi, Cyrus, Okunji, Christopher C., Iwu, Maurice M., Schuster, Brian M., Sterner, Olov

Journal:

Natural Product Communications

Year:

2006

Language:

english

File:

PDF, 67 KB

english, 2006

12

Putrescine activated S-adenosylmethionine decarboxylase fromTrypanosoma brucei brucei

Babu L. Tekwani, Cyrus J. Bacchi, Anthony E. Pegg

Journal:

Molecular and Cellular Biochemistry

Year:

1992

Language:

english

File:

PDF, 747 KB

english, 1992

13

Polyamine Synthesis and Interconversion by the Microsporidian Encephalitozoon cuniculi

CYRUS J. BACCHI, SCHENNELLA LANE, LOUIS M. WEISS, NIGEL YARLETT, PETER TAKVORIAN, MURRAY WITTNER

Journal:

Journal of Eukaryotic Microbiology

Year:

2001

Language:

english

File:

PDF, 1.74 MB

english, 2001

14

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Vanden Eynde, Jean, Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus, Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien

Journal:

Pharmaceuticals

Year:

2016

Language:

english

File:

PDF, 627 KB

english, 2016

15

Inhibition of trichomonas vaginalis ornithine decarboxylase by amino acid analogs

Nigel Yarlett, Burt Goldberg, M. Ali Moharrami, Cyrus J. Bacchi

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1017 KB

english, 1992

16

Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice

Cyrus J. Bacchi, Henry C. Nathan, Seymour H. Hutner, David S. Duch, Charles A. Nichol

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 363 KB

english, 1981

17

Polyamines stimulate natural RNA-directed DNA synthesis by Rauscher murine leukemia virus DNA polymerase

Stuart L. Marcus, Steven W. Smith, Cyrus J. Bacchi

Journal:

Biochemical and Biophysical Research Communications

Year:

1981

Language:

english

File:

PDF, 433 KB

english, 1981

18

Rapid Methylation of Cell Proteins and Lipids in Trypanosoma brucei

BURT GOLDBERG, NIGEL YARLETT, DONNA RATTENDI, DAVID LLOYD, CYRUS J. BACCHI

Journal:

Journal of Eukaryotic Microbiology

Year:

1997

Language:

english

File:

PDF, 743 KB

english, 1997

19

O2-Polarographic Studies on Soluble and Mitochondrial Enzymes of Crithidia fasciculata; Glycerophosphate Enzymes

CYRUS J. BACCHI, S. H. HUTNER, E. I. CIACCIO, S. M. MARCUS

Journal:

Journal of Eukaryotic Microbiology

Year:

1968

Language:

english

File:

PDF, 947 KB

english, 1968

20

Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis

Alan J. Bitonti, Cyrus J. Bacchi, Peter P. McCann, Albert Sjoerdsma

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 382 KB

english, 1985

21

Chromatographic resolution of two DNA polymerase activities from bloodstream forms of Trypanosoma brucei: Differential responses to exogenous polyamine addition

Stuart L. Marcus, Gregg Lipschik, Generosa Trueba, Cyrus J. Bacchi

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 482 KB

english, 1980

22

Trypanocidal Activity of Conformationally Restricted Pentamidine Congeners

Donkor, Isaac O., Huang, Tien L., Tao, Bin, Rattendi, Donna, Lane, Schennella, Vargas, Marc, Goldberg, Burt, Bacchi, Cyrus

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

23

Content, Synthesis, and Function of Polyamines in Trypanosomatids: Relationship to Chemotherapy,

CYRUS J. BACCHI

Journal:

Journal of Eukaryotic Microbiology

Year:

1981

Language:

english

File:

PDF, 927 KB

english, 1981

24

Effects of Carboxylemethylation and Polyamine Synthesis Inhibitors on Methylation of Trypanosoma brucei Cellular Proteins and Lipids

BURT GOLDBERG, DONNA RATTENDI, NIGEL YARLETT, DAVID LLOYD, CYRUS J. BACCHI

Journal:

Journal of Eukaryotic Microbiology

Year:

1997

Language:

english

File:

PDF, 822 KB

english, 1997

25

Polyamine inhibitors in antimicrobial chemotherapy

Tyms, A. Stanley, Williamson, John D., Bacchi, Cyrus J.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1988

Language:

english

File:

PDF, 1.60 MB

english, 1988

26

Oxaloacetate Production via Carboxylations in Crithidia fasciculata Preparations

CYRUS J. BACCHI, E. I. CIACCIO, DAVID B. KABACK, S. H. HUTNER

Journal:

Journal of Eukaryotic Microbiology

Year:

1970

Language:

english

File:

PDF, 722 KB

english, 1970

27

Effect of dl-α-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei

Nigel Yarlett, Cyrus J. Bacchi

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 728 KB

english, 1988

28

The Importance of the 4′-Hydroxyl Hydrogen for the Anti-trypanosomal and Antiviral Properties of (+)-5′-Noraristeromycin and Two 7-Deaza Analogues

Katherine L. Seley, Stewart W. Schneller, Erik De Clercq, Donna Rattendi, Schenella Lane, Cyrus J. Bacchi, Brent Korba

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 126 KB

english, 1998

29

Effects of Intermediates of Methionine Metabolism and Nucleoside Analogs on S-Adenosylmethionine Transport by Trypanosoma brucei brucei and a Drug-resistant Trypanosoma brucei rhodesiense

Burt Goldberg, Donna Rattendi, David Lloyd, Janice R Sufrin, Cyrus J Bacchi

Journal:

Biochemical Pharmacology

Year:

1998

Language:

english

File:

PDF, 392 KB

english, 1998

30

SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei

Joe B. Perales, Jennifer Freeman, Cyrus J. Bacchi, Tana Bowling, Robert Don, Eric Gaukel, Luke Mercer, Joseph A. Moore III, Bakela Nare, Tien M. Nguyen, Robert A. Noe, Ryan Randolph, Cindy Rewerts, St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 297 KB

english, 2011

31

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue III, Michelle Boahbedason, Ronghui Wu, Patrick M. Woster, Robert A. Casero Jr., Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 310 KB

english, 1996

32

Expression of Cardiac Cytokines and Inducible Form of Nitric Oxide Synthase (NOS2) inTrypanosoma cruzi-infected Mice

Huan Huang, John Chan, Murray Wittner, Linda A. Jelicks, Stephen A. Morris, Stephen M. Factor, Louis M. Weiss, Vicki L. Braunstein, Cyrus J. Bacchi, Nigel Yarlett, Madhulika Chandra, Jamshid Shirani,

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1999

Language:

english

File:

PDF, 3.55 MB

english, 1999

33

ChemInform Abstract: Novel Alkylpolyamine Analogues that Possess Both Antitrypanosomal and Antimicrosporidial Activity.

Yu Zou, Zhiqian Wu, Nilantha Sirisoma, Patrick M. Woster, Robert A. Casero Jr., Louis M. Weiss, Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

Journal:

Year:

2001

File:

PDF, 27 KB

2001

34

Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

Tien L. Huang, Jean Jacques Vanden Eynde, Annie Mayence, Margaret S. Collins, Melanie T. Cushion, Donna Rattendi, Indira Londono, Lakshman Mazumder, Cyrus J. Bacchi, Nigel Yarlett

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 293 KB

english, 2009

35

Use of difluoromethylornithine (DFMO, eflornithine) for late-stage African trypanosomiasis

Peter P. McCann, Alan J. Bitonti, Cyrus J. Bacchi, Allen B. Clarkson Jr

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1987

Language:

english

File:

PDF, 127 KB

english, 1987

36

Inhibitors of histamine metabolism in vitro and in vivo: Correlations with antitrypanosomal activity

David S. Duch, Cyrus J. Bacchi, Mark P. Edelstein, Charles A. Nichol

Journal:

Biochemical Pharmacology

Year:

1984

Language:

english

File:

PDF, 801 KB

english, 1984

37

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities

O’Sullivan, Mary C., Durham, Timothy B., Valdes, Hannah E., Dauer, Kelly L., Karney, Nicholas J., Forrestel, Andrew C., Bacchi, Cyrus J., Baker, Jerome F.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 12.44 MB

english, 2015

38

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

Vanden Eynde, Jean, Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus, Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien

Journal:

Pharmaceuticals

Year:

2016

File:

PDF, 627 KB

2016

39

ChemInform Abstract: Trypanocidal Activity of Dicationic Compounds Related to Pentamidine.

Isaac O. Donkor, Haregewein Assefa, Donna Rattendi, Schennella Lane, Marc Vargas, Burt Goldberg, Cyrus Bacchi

Journal:

Year:

2002

File:

PDF, 28 KB

2002

40

Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug

Tien L. Huang, Cyrus J. Bacchi, Nageswara R. Kode, Qiang Zhang, Guangdi Wang, Nigel Yartlet, Donna Rattendi, Indira Londono, Lakshman Mazumder, Jean Jacques Vanden Eynde, Annie Mayence, Isaac O. Donko

Journal:

International Journal of Antimicrobial Agents

Year:

2007

Language:

english

File:

PDF, 322 KB

english, 2007

41

(+)-7-Deaza-5‘-noraristeromycin as an Anti-Trypanosomal Agent

Seley, Katherine L., Schneller, Stewart W., Rattendi, Donna, Bacchi, Cyrus J.

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 106 KB

english, 1997

42

Purine 2′, 3′-acyclonucleosides: Improved synthesis and antiparasitic actimity

Janice R. Sufrin, Arthur J. Spiess, Canio J. Marasco Jr., Simon L. Croft, Diane Snowdon, Vanessa Yardley, Cyrus J Bacchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 226 KB

english, 1995

43

Polyamine Metabolism as a Therapeutic Target for Microsporidia

CHRISTINA COYLE, CYRUS BACCHI, NIGEL YARLETT, HERBERT B. TANOWITZ, MURRAY WITTNER, LOUIS M. WEISS

Journal:

Journal of Eukaryotic Microbiology

Year:

1996

Language:

english

File:

PDF, 136 KB

english, 1996

44

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity

Xiangdong Bi, Christina Lopez, Cyrus J. Bacchi, Donna Rattendi, Patrick M. Woster

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 123 KB

english, 2006

45

In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei

Cyrus J. Bacchi, Joanne Garofalo, Dianne Mockenhaupt, Peter P. McCann, Keith A. Diekema, Anthony E. Pegg, Henry C. Nathan, Elizabeth A. Mullaney, Laura Chunosoff, Albert Sjoerdsma, Seymour H. Hutner

Journal:

Molecular and Biochemical Parasitology

Year:

1983

Language:

english

File:

PDF, 864 KB

english, 1983

46

Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4′-diacetyldiphenylurea bis(guanylhydrazone) (DDUG)

Stuart L. Marcus, Henry C. Nathan, Seymour H. Hutner, Cyrus J. Bacchi

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 365 KB

english, 1987

47

Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-α-difluoromethylornithine; reversal by polyamines

Cyrus J. Bacchi, Henry C. Nathan, Seymour H. Hutner, Peter P. McCann, Albert Sjoerdsma

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 475 KB

english, 1982

48

[Part 1: Biological Sciences] || Efficacy of Combinations of Difluoromethylornithine and Bleomycin in a Mouse Model of Central Nervous System African Trypanosomiasis

Allen B. Clarkson, Cyrus J. Bacchi, George H. Mellow, Henry C. Nathan, Peter P. McCann and Albert Sjoerdsma

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 1.16 MB

english, 1983

49

Polyamine Depletion Following Exposure to DL-α-Difluoromethylornithine Both In Vivo and In Vitro Initiates Morphological Alterations and Mitochondrial Activation in a Monomorphic Strain of Trypanosoma brucei brucei

BRUCE F. GIFFIN, PETER P. McCANN, ALAN J. BITONTI, CYRUS J. BACCHI

Journal:

Journal of Eukaryotic Microbiology

Year:

1986

Language:

english

File:

PDF, 767 KB

english, 1986

50

Inhibition by Several Standard Antiprotozoal Drugs of Growth and O2 Uptake of Cells and Particulate Preparations of a Leptomonas

BURT GOLDBERG, CHRIS LAMBROS, CYRUS J. BACCHI, S. H. HUTNER

Journal:

Journal of Eukaryotic Microbiology

Year:

1974

Language:

english

File:

PDF, 596 KB

english, 1974

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